Wharton’s Jelly And Its Stem Cell
The human umbilical cord consists of two arteries and one vein buried within the Wharton’s Jelly, a mucoid connective tissue and fibroblast-like cells that channel between the evolving embryo or fetus and the placenta. Wharton’s Jelly contains a profuse amount of Mesenchymal Stem Cells (MSCs).
In the 1950s, scientists have discovered that there are generally two kinds of adult stem cells: the Hematopoietic Stem Cells (HSCs) and MSCs, found mostly in bone marrow. HSCs are also found in peripheral blood and cord blood and are widely being used in treating cancers of blood such as leukemia and lymphoma.
Meanwhile, MSCs are the most significant source of adult stem cells that are involved in the regeneration of tissues with mesenchymal origin such as the bone, cartilage, muscle, tendon and adipose tissue.
- M, et al. Immunomodulatory Effects of Human Umbilical Cord Wharton’s Jelly-Derived Mesenchymal Stem Cells on Differentiation, Maturation and Endocytosis of Monocyte-Derived Dendritic Cells, March 2013; 12(1): 37-49.
- Dae-Won Kim, et al. Wharton’s Jelly-Derived Mesenchymal Stem Cells: Phenotypic Characterization and Optimizing Their Therapeutic Potential for Clinical Applications, 2013, 14(6), 11692-11712.